Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

X Zhu, J Xu, G Ling, P Zhang - Chemical Society Reviews, 2023 - pubs.rsc.org
Various binding modes of tunable metal organic frameworks (MOFs) and functional
DNAzymes (Dzs) synergistically catalyze the emergence of abundant functional …

[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Autonomous chemistry enabling environment-adaptive electrochemical energy storage devices

Z Lv, W Li, J Wei, F Ho, J Cao, X Chen - CCS Chemistry, 2023 - chinesechemsoc.org
Next-generation electronics that are fused into the human body can play a key role in future
intelligent communication, smart healthcare, and human enhancement applications. As a …

Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes

M Coluccia, V Parisse, P Guglielmi, G Giannini… - European Journal of …, 2022 - Elsevier
Metal-organic frameworks (MOF) have been studied for infinite applications. Among these,
anticancer therapy has surely attracted great interest due to the intrinsic characteristics of …

miRNA-guided imaging and photodynamic therapy treatment of cancer cells using Zn (II)-protoporphyrin IX-loaded metal–organic framework nanoparticles

P Zhang, Y Ouyang, YS Sohn, M Fadeev, O Karmi… - ACS …, 2022 - ACS Publications
An analytical platform for the selective miRNA-21-guided imaging of breast cancer cells and
miRNA-221-guided imaging of ovarian cancer cells and the selective photodynamic therapy …

A novel ratiometric electrochemical biosensor using only one signal tag for highly reliable and ultrasensitive detection of miRNA-21

L Kong, H Li, X Zhang, Y Zhuo, Y Chai… - Analytical …, 2022 - ACS Publications
Herein, a novel ratiometric electrochemical biosensor with methylene blue (MB) as the only
one signal tag was proposed for highly reliable and ultrasensitive detection of microRNA-21 …

An intracellular self‐assembly‐driven uninterrupted ROS generator augments 5‐aminolevulinic‐acid‐based tumor therapy

J Shi, W Nie, X Zhao, X Yang, H Cheng… - Advanced …, 2022 - Wiley Online Library
Free radical therapy based on 5‐aminolevulinic acid (ALA, a precursor of the
photosensitizer protoporphyrin IX (PpIX)) has been approved by the US Food and Drug …

Orthogonal enzyme-driven timers for DNA strand displacement reactions

J Bucci, P Irmisch, E Del Grosso… - Journal of the …, 2022 - ACS Publications
Here, we demonstrate a strategy to rationally program a delayed onset of toehold-mediated
DNA strand displacement reactions (SDRs). The approach is based on blocker strands that …

Triple-probe DNA framework-based transistor for SARS-CoV-2 10-in-1 pooled testing

Y Wu, D Ji, C Dai, D Kong, Y Chen, L Wang, M Guo… - Nano Letters, 2022 - ACS Publications
Accurate and population-scale screening technology is crucial in the control and prevention
of COVID-19, such as pooled testing with high overall testing efficiency. Nevertheless …

[HTML][HTML] Surface engineered metal-organic frameworks as active targeting nanomedicines for mono-and multi-therapy

R Masoudifar, N Pouyanfar, D Liu, M Ahmadi… - Applied Materials …, 2022 - Elsevier
The precision tenability of metal-organic frameworks (MOFs) enables the efficient
encapsulation of a wide variety of small-molecule pharmaceuticals and macromolecular …