Creating new antifoulants using the tools and tactics of medicinal chemistry

PL Cahill, LWK Moodie, C Hertzer… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus The unwanted accumulation of marine micro-and macroorganisms such as
algae and barnacles on submerged man-made structures and vessel hulls is a major …

Design and synthesis of bioinspired nanomaterials for biomedical application

K Tang, J Xue, Y Zhu, C Wu - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Natural materials and bioprocesses provide abundant inspirations for the design and
synthesis of high‐performance nanomaterials. In the past several decades, bioinspired …

Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials

J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

Progress towards the clinical use of antimicrobial peptides: challenges and opportunities

P Espinal, E Fusté, JM Sierra… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction To overcome the challenge of multidrug resistance, natural and synthetic
peptides are candidates to become the basis of innovative therapeutics, featuring diverse …

Pyrgos[n]cages: Redefining antibacterial strategy against drug resistance

Y Zhang, M Luo, X Shi, A Li, W Zhou, Y Yin, H Wang… - Science …, 2024 - science.org
Amid rising antibiotic resistance, the quest for advanced antibacterial agents to surpass
microbial adaptation is paramount. This study introduces Pyrgos [n] cages (n= 1 to 4) …

Exploring the Sequence Space of Antimicrobial Peptide Dendrimers

X Cai, A Capecchi, B Olcay, M Orsi… - Israel Journal of …, 2023 - Wiley Online Library
There is an urgent need to develop new antibacterial agents against multidrug resistant
bacteria. Herein we report our investigation of antimicrobial peptide dendrimers (AMPDs) …

[HTML][HTML] α, α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal

D Ausbacher, LA Miller, DM Goeres, PS Stewart… - Biofilm, 2023 - Elsevier
Bacterial biofilms account for up to 80% of all infections and complicate successful therapies
due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the …

In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide

Z Li, Y Shui, H Wang, S Li, B Deng, W Zhang… - Probiotics and …, 2024 - Springer
The increasing infection and drug resistance frequency has encouraged the exploration of
new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion …

Nature-inspired peptide antifouling biocide: coating compatibility, field validation, and environmental stability

P Cahill, TM Grant, D Rennison… - ACS Applied Bio …, 2023 - ACS Publications
This study reports the development of a class of eco-friendly antifouling biocides based on a
cyclic dipeptide scaffold, 2, 5-diketopiperazine (2, 5-DKP). The lead compound cyclo (N-Bip …

Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents

AJ Craig, Y Ermolovich, A Cameron… - ACS Medicinal …, 2023 - ACS Publications
Small synthetic mimics of cationic antimicrobial peptides represent a promising class of
compounds with leads in clinical development for the treatment of persistent microbial …