Creating new antifoulants using the tools and tactics of medicinal chemistry
PL Cahill, LWK Moodie, C Hertzer… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus The unwanted accumulation of marine micro-and macroorganisms such as
algae and barnacles on submerged man-made structures and vessel hulls is a major …
algae and barnacles on submerged man-made structures and vessel hulls is a major …
Design and synthesis of bioinspired nanomaterials for biomedical application
K Tang, J Xue, Y Zhu, C Wu - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Natural materials and bioprocesses provide abundant inspirations for the design and
synthesis of high‐performance nanomaterials. In the past several decades, bioinspired …
synthesis of high‐performance nanomaterials. In the past several decades, bioinspired …
Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials
J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …
Progress towards the clinical use of antimicrobial peptides: challenges and opportunities
Introduction To overcome the challenge of multidrug resistance, natural and synthetic
peptides are candidates to become the basis of innovative therapeutics, featuring diverse …
peptides are candidates to become the basis of innovative therapeutics, featuring diverse …
Pyrgos[n]cages: Redefining antibacterial strategy against drug resistance
Y Zhang, M Luo, X Shi, A Li, W Zhou, Y Yin, H Wang… - Science …, 2024 - science.org
Amid rising antibiotic resistance, the quest for advanced antibacterial agents to surpass
microbial adaptation is paramount. This study introduces Pyrgos [n] cages (n= 1 to 4) …
microbial adaptation is paramount. This study introduces Pyrgos [n] cages (n= 1 to 4) …
Exploring the Sequence Space of Antimicrobial Peptide Dendrimers
There is an urgent need to develop new antibacterial agents against multidrug resistant
bacteria. Herein we report our investigation of antimicrobial peptide dendrimers (AMPDs) …
bacteria. Herein we report our investigation of antimicrobial peptide dendrimers (AMPDs) …
[HTML][HTML] α, α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
Bacterial biofilms account for up to 80% of all infections and complicate successful therapies
due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the …
due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the …
In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide
Z Li, Y Shui, H Wang, S Li, B Deng, W Zhang… - Probiotics and …, 2024 - Springer
The increasing infection and drug resistance frequency has encouraged the exploration of
new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion …
new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion …
Nature-inspired peptide antifouling biocide: coating compatibility, field validation, and environmental stability
P Cahill, TM Grant, D Rennison… - ACS Applied Bio …, 2023 - ACS Publications
This study reports the development of a class of eco-friendly antifouling biocides based on a
cyclic dipeptide scaffold, 2, 5-diketopiperazine (2, 5-DKP). The lead compound cyclo (N-Bip …
cyclic dipeptide scaffold, 2, 5-diketopiperazine (2, 5-DKP). The lead compound cyclo (N-Bip …
Antimicrobial Peptides Incorporating Halogenated Marine-Derived Amino Acid Substituents
AJ Craig, Y Ermolovich, A Cameron… - ACS Medicinal …, 2023 - ACS Publications
Small synthetic mimics of cationic antimicrobial peptides represent a promising class of
compounds with leads in clinical development for the treatment of persistent microbial …
compounds with leads in clinical development for the treatment of persistent microbial …