Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …

Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

In addition to fatty acids, glucose and lactate are important myocardial substrates under
physiologic and stress conditions. They are metabolized to pyruvate, which enters …

Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and
alternatively serve as a fuel source for peripheral tissues including the brain, heart, and …

The impact of chronic caloric restriction (CR) on health and survival is complex with poorly
understood underlying molecular mechanisms. A recent study in mice addressing the diets …

Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose
and fatty acids are essential substrates for ATP and biomass production; however, the …