Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects

V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
Simple Summary The application of non-steroidal anti-inflammatory drugs (NSAIDs) in
cancer therapy has been a widely studied topic for almost four decades. This review …

Platinum prodrug nanoparticles with COX‐2 inhibition amplify pyroptosis for enhanced chemotherapy and immune activation of pancreatic cancer

B Yu, Y Wang, T Bing, Y Tang, J Huang… - Advanced …, 2024 - Wiley Online Library
Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to
trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can …

Recent advances in drug delivery and targeting for the treatment of pancreatic cancer

N Pramanik, A Gupta, Y Ghanwatkar… - Journal of Controlled …, 2024 - Elsevier
Despite significant treatment efforts, pancreatic ductal adenocarcinoma (PDAC), the
deadliest solid tumor, is still incurable in the preclinical stages due to multifacet stroma …

Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells

L Gorchs, C Fernández Moro, P Bankhead… - Frontiers in …, 2019 - frontiersin.org
Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma
of pancreatic ductal adenocarcinomas and besides their pathological release of …

Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma

IJ Hawthorne, H Dunbar, C Tunstead, T Schorpp… - Molecular Therapy, 2023 - cell.com
Current asthma therapies focus on reducing symptoms but fail to restore existing structural
damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway …

The anti-breast cancer stem cell properties of gold (I)-non-steroidal anti-inflammatory drug complexes

A Johnson, C Olelewe, JH Kim, J Northcote-Smith… - Chemical …, 2023 - pubs.rsc.org
The anti-breast cancer stem cell (CSC) properties of a series of gold (I) complexes
comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine …

Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis

W Li, L Sun, J Lei, Z Wu, Q Ma… - Oncology …, 2020 - spandidos-publications.com
Hypoxic microenvironment and pancreatic stellate cells (PSCs) play important roles in
pancreatic cancer progression. PSCs secrete a number of soluble factors, such as …

A novel zinc phthalocyanine-indometacin photosensitizer with “Three-in-one” cyclooxygenase-2-driven dual targeting and aggregation inhibition for high-efficient …

K Huang, H Zhang, M Yan, J Xue, J Chen - Dyes and Pigments, 2022 - Elsevier
Photodynamic therapy, during which nontoxic photosensitizers can be photo-activated to
generate cytotoxic reactive oxygen species, has attracted great interest. However, the strong …

The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer

M Mecca, S Picerno, S Cortellino - International Journal of Molecular …, 2024 - mdpi.com
Inflammation is a key contributor to both the initiation and progression of tumors, and it can
be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors …

Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5-LOX by molecular docking and dynamic …

KN Hemavathi, S Skariyachan, R Raju… - Computers in Biology …, 2024 - Elsevier
Inflammation plays a pivotal role in various pathological processes, ranging from routine
injuries and infections to cancer. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) …