Health benefits of quercetin in age-related diseases

Deepika, PK Maurya - Molecules, 2022 - mdpi.com
Polyphenols are the known group of phytochemicals that essentially consists of phenolic
rings. These are the plant product present in varied fruits and vegetables. These secondary …

Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections

P González, P Lozano, G Ros, F Solano - International Journal of …, 2023 - mdpi.com
This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Biocatalytic and antioxidant nanostructures for ROS scavenging and biotherapeutics

L Wang, B Zhu, Y Deng, T Li, Q Tian… - Advanced Functional …, 2021 - Wiley Online Library
In human systems, reactive oxygen species (ROS) significantly affect different physiological
activities and play critical roles in diverse living processes. It is widely known that excessive …

Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

L Cong, MY Lei, ZQ Liu, ZF Liu, Z Ma, K Liu, J Li… - Food and Chemical …, 2021 - Elsevier
Exposure to excess levels of manganese (Mn) leads to neurotoxicity. Increasing evidence
demonstrates that oxidative stress and neuroinflammation are important pathological causes …

Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

X Xu, L Xu, J Xia, C Wen, Y Liang, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Osteoarthritis (OA) is a widespread clinical disease characterized by cartilage degeneration
in middle-aged and elderly people. Currently, there is no effective treatment for OA apart …

The implication of reactive oxygen species and antioxidants in knee osteoarthritis

NB Tudorachi, EE Totu, A Fifere, V Ardeleanu… - Antioxidants, 2021 - mdpi.com
Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential
challenge for public health, with a negative impact on the geriatric patient's quality of life …

Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

H Lu, C Jia, D Wu, H Jin, Z Lin, J Pan, X Li… - Cell Death & …, 2021 - nature.com
Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence and
currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as a potent …

Lipid peroxidation in osteoarthritis: Focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis

X Zhang, L Hou, Z Guo, G Wang, J Xu, Z Zheng… - Cell Death …, 2023 - nature.com
Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that
affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of …

Functional biomaterials for osteoarthritis treatment: from research to application

Y Lei, Q Zhang, G Kuang, X Wang, Q Fan… - Smart Medicine, 2022 - Wiley Online Library
Osteoarthritis (OA) is a common disease that endangers millions of middle‐aged and elderly
people worldwide. Researchers from different fields have made great efforts and achieved …