Subcellular organization of the cAMP signaling pathway

M Zaccolo, A Zerio, MJ Lobo - Pharmacological reviews, 2021 - ASPET
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Proposed mechanisms of photobiomodulation or low-level light therapy

LF De Freitas, MR Hamblin - IEEE Journal of selected topics in …, 2016 - ieeexplore.ieee.org
Photobiomodulation also known as low-level laser (or light) therapy (LLLT), has been known
for almost 50 years but still has not gained widespread acceptance, largely due to …

[HTML][HTML] Mutations in SARS-CoV-2 structural proteins: a global analysis

M Abavisani, K Rahimian, B Mahdavi, S Tokhanbigli… - Virology Journal, 2022 - Springer
Background Emergence of new variants mainly variants of concerns (VOC) is caused by
mutations in main structural proteins of severe acute respiratory syndrome coronavirus 2 …

The corticotropin-releasing factor family: physiology of the stress response

JM Deussing, A Chen - Physiological reviews, 2018 - journals.physiology.org
The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

[HTML][HTML] Nanoscale surveillance of the brain by microglia via cAMP-regulated filopodia

LP Bernier, CJ Bohlen, EM York, HB Choi, A Kamyabi… - Cell reports, 2019 - cell.com
Microglia, the brain's immune cells, maintain homeostasis and sense pathological changes
by continuously surveying the parenchyma with highly motile large processes. Here, we …

Schwann cell myelination

JL Salzer - Cold Spring Harbor perspectives in biology, 2015 - cshperspectives.cshlp.org
Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Signalling scaffolds and local organization of cellular behaviour

LK Langeberg, JD Scott - Nature reviews Molecular cell biology, 2015 - nature.com
Cellular responses to environmental cues involve the mobilization of GTPases, protein
kinases and phosphoprotein phosphatases. The spatial organization of these signalling …

Mechanisms of action of glucagon-like peptide 1 in the pancreas

ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

The signaling pathways regulating NLRP3 inflammasome activation

M Chen, X Ye, X He, D Ouyang - Inflammation, 2021 - Springer
The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …