Calcitonin gene-related peptide: physiology and pathophysiology

FA Russell, R King, SJ Smillie, X Kodji… - Physiological …, 2014 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

[HTML][HTML] The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects

Z Kee, X Kodji, SD Brain - Frontiers in physiology, 2018 - frontiersin.org
Calcitonin gene-related peptide (CGRP) is a highly potent vasoactive peptide released from
sensory nerves, which is now proposed to have protective effects in several cardiovascular …

[HTML][HTML] H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

M Eberhardt, M Dux, B Namer, J Miljkovic… - Nature …, 2014 - nature.com
Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways
with pharmacological endpoints of high significance in the treatment of heart failure …

Wiping out CGRP: potential cardiovascular risks

A MaassenVanDenBrink, J Meijer, CM Villalón… - Trends in …, 2016 - cell.com
Migraine is a common episodic neurovascular brain disorder associated with increased risk
of cardio-and cerebrovascular ischemia. Migraine headache is likely caused by activation of …

[HTML][HTML] CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

V Favoni, L Giani, L Al-Hassany, GM Asioli… - The journal of headache …, 2019 - Springer
Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the
pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with …

[HTML][HTML] Protective role of α-calcitonin gene-related peptide in cardiovascular diseases

A Kumar, JD Potts, DJ DiPette - Frontiers in physiology, 2019 - frontiersin.org
α-Calcitonin gene-related peptide (α-CGRP) is a regulatory neuropeptide of 37 amino acids.
It is widely distributed in the central and peripheral nervous system, predominantly in cell …

[HTML][HTML] The regulation of pulmonary vascular tone by neuropeptides and the implications for pulmonary hypertension

CCW Lo, SM Moosavi, KJ Bubb - Frontiers in physiology, 2018 - frontiersin.org
Pulmonary hypertension (PH) is an incurable, chronic disease of small pulmonary vessels.
Progressive remodeling of the pulmonary vasculature results in increased pulmonary …

Cardiorespiratory function associated with dietary nitrate supplementation

V Bond Jr, BH Curry, RG Adams… - Applied physiology …, 2014 - cdnsciencepub.com
The advent of medical nutrition therapy and nutritional physiology affords the opportunity to
link diet to specific cardiovascular mechanisms, suggesting novel treatments for …

[HTML][HTML] Calcitonin gene-related peptide regulates cardiomyocyte survival through regulation of oxidative stress by PI3K/Akt and MAPK signaling pathways

NA Umoh, RK Walker, RM Millis… - Annals of clinical and …, 2014 - ncbi.nlm.nih.gov
CGRP and specific CGRP receptors are found in the heart where they produce positive-
inotropic and anti-apoptotic effects, key adaptations to exercise and cardiovascular disease …

Understanding CGRP and cardiovascular risk

E Rubio-Beltrán, AM van den Brink - Calcitonin gene-related peptide …, 2019 - Springer
Increasing knowledge about the role of calcitonin gene-related peptide (CGRP) in migraine
pathophysiology has led to the development of antibodies against this peptide or its …