RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present
study, we found that the RNA helicase DDX5 was downregulated in keratinocytes from the …

Alternative splicing (AS) of precursor mRNA (pre-mRNA) is a cellular post-transcriptional
process that generates protein isoform diversity. Nonsense-mediated RNA decay (NMD) is …

High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene
expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing …

Neoantigen production is a determinant of cancer immunotherapy. However, the expansion
of neoantigen abundance for cancer therapeutics is technically challenging. Here, we report …

Simple Summary Alternative splicing is one of the most fabulous and important mechanism
in the cell. Alternative splicing is capable of generating many proteins from a single gene …

Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …

Epigenetic processes including RNA methylation, post-translational modifications, and non-
coding RNA expression have been associated with the heritable risks of systemic lupus …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …