Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Historically, medical imaging has been a qualitative or semi-quantitative modality. It is
difficult to quantify what can be seen in an image, and to turn it into valuable predictive …

The concept of empathy has received a lot of attention in the past few decades in public
media, academia, national and international politics, arts, ethics, health professions …

The past 60 years have seen huge advances in many of the scientific, technological and
managerial factors that should tend to raise the efficiency of commercial drug research and …

Although the potential for genomics to contribute to clinical care has long been anticipated,
the pace of defining the risks and benefits of incorporating genomic findings into medical …

In response to a need for a general catalog of genome variation to address the large-scale
sampling designs required by association studies, gene mapping and evolutionary biology …

Therapeutic drug monitoring (TDM) is the clinical practice of measuring specific drugs at
designated intervals to maintain a constant concentration in a patient's bloodstream, thereby …

Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other
drug targets have been linked to interindividual differences in the efficacy and toxicity of …

Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …