Defective expression or function of the cystic fibrosis transmembrane conductance regulator
(CFTR) underlies the hypersusceptibility of cystic fibrosis (CF) patients to chronic airway …

Objectives: Identify the appropriate indications for tobramycin therapy in the treatment of
various infections. Apply evidence-based guidelines and recommendations when selecting …

Cystic fibrosis (CF) is a complex, potentially life-threatening disease that is most effectively
treated through the administration of antibiotics (eg, colistimethate sodium). Chronic …

BACKGROUND: Reducing nebulisation times for tobramycin solution for inhalation in cystic
fibrosis (CF) may improve compliance. METHODS: In this single-dose, open-label, two-way …

BACKGROUND: Nebulization times have been identified as an issue in patient compliance
with tobramycin solution for inhalation (TSI) therapy in cystic fibrosis (CF). METHODS: In this …

Background: Cystic fibrosis is the most common incurable hereditary disease in the US.
Persistent respiratory infection is the leading cause of morbidity and mortality in cystic …

Background The COVID-19 pandemic disrupted the needs and concerns of the cystic
fibrosis community. Patients with cystic fibrosis were particularly vulnerable during the …

Background Inhaled tobramycin is important in the treatment of Pseudomonas aeruginosa
(Pa) infections in cystic fibrosis (CF). However, despite its use it fails to attenuate the clinical …

Abstract Background: Pseudomonas aeruginosa (Pa) is the predominant pathogen infecting
the airways of patients with cystic fibrosis (CF). Initial colonization is usually transient and …

Data regarding the role of inhaled colistin in critically ill pediatric patients without cystic
fibrosis are scarce. Three children (one female), admitted to the intensive care unit (ICU) of a …