When questioned, about 10% of the parents report suspected hypersensitivity to at least one
drug in their children. However, only a few of these reactions can be confirmed as allergic …

Background Adverse drug reactions in children are an important public health problem. We
have undertaken a systematic review of observational studies in children in three settings …

Health services throughout the world strive to provide care to people when they are unwell
and assist them to stay well. Primary care services are increasingly at the heart of integrated …

The aim was to compare results of studies performed in different settings worldwide and
identify common therapeutic areas to allow for focused interventions, because off-label drug …

Purpose The aim of this review is to assess the extent of the use of off-label and/or
unlicenced drugs among hospitalised children. Methods A systematic search was made in …

Off‐label prescribing is the prescription of a registered medicine for a use that is not included
in the product information. The practice is common, with rates up to 40% in adults and up to …

This review aims to give an updated overview of the worldwide situation of off-label and
unlicensed drug use in the paediatric field, also taking into account the safety of this kind of …

Objective To provide an overview of drug use in children in three European countries.
Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the …

Objective: To assess the incidence of adverse drug reactions (ADRs) in the paediatric
population and the safety alerts concerning children and adolescents issued by international …

Objectives: In paediatric pharmacotherapy, many drugs are prescribed to be given in ways
and for conditions not approved in the marketing authorization (MA). Thus, off‐label …