Epidemiology and pathophysiology of Takotsubo syndrome

YJ Akashi, HM Nef, AR Lyon - Nature Reviews Cardiology, 2015 - nature.com
Takotsubo syndrome is an acute cardiac syndrome first described in 1990 and characterized
by transient left ventricular dysfunction affecting more than one coronary artery territory, often …

Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning

AR Lyon, PSC Rees, S Prasad… - Nature clinical practice …, 2008 - nature.com
Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy, is an increasingly
recognized clinical syndrome characterized by acute reversible apical ventricular …

Takotsubo syndrome: getting closer to its causes

MM Akhtar, VL Cammann, C Templin… - Cardiovascular …, 2023 - academic.oup.com
Takotsubo syndrome (TTS) accounts for between 1 and 4% of cases presenting clinically as
an acute coronary syndrome. It typically presents as a transient cardiac phenotype of left …

The role of estrogen and estrogen receptors on cardiomyocytes: an overview

T Luo, JK Kim - Canadian Journal of Cardiology, 2016 - Elsevier
Sex differences in the onset and manifestation of cardiovascular diseases are well known,
yet the mechanism behind this discrepancy remains obscure. Estrogen and its …

Influence of sex hormones and phytoestrogens on heart disease in men and women

P Bhupathy, CD Haines, LA Leinwand - Women's health, 2010 - journals.sagepub.com
Cardiovascular disease (CVD) is the number one cause of morbidity and mortality in men
and women worldwide. According to the WHO, by 2015, almost 20 million people will die …

Molecular mechanisms of takotsubo syndrome

LS Couch, K Channon, T Thum - International Journal of Molecular …, 2022 - mdpi.com
Takotsubo syndrome (TTS) is a severe but reversible acute heart failure syndrome that
occurs following high catecholaminergic stress. TTS patients are similar to those with acute …

Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease

SP Tofovic - Journal of cardiovascular pharmacology, 2010 - journals.lww.com
Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of
endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric …

The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes

R Lappano, AG Recchia, EM De Francesco… - PloS one, 2011 - journals.plos.org
Background The hydroxylated derivatives of cholesterol, such as the oxysterols, play
important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25HC) has been …

Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity

A Ruggieri, C Barbati, W Malorni - International journal of …, 2010 - Wiley Online Library
Hepatocellular carcinoma (HCC) represents the most common primary liver cancer and one
of the most fatal human cancers. Besides alcoholic liver disease as well as genetic and …

Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism

J Cai, Y Hong, C Weng, C Tan… - American Journal …, 2011 - journals.physiology.org
Growing evidences support that androgen displays beneficial effects on cardiovascular
functions although the mechanism of androgen actions remains to be elucidated …