Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …

Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …

Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The
virus efficiently infects resting human B lymphocytes and induces their continuous …

The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …

Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere
erosion and mitochondrial injury, leading to impaired cellular functions and cell death …

We lack a mechanistic understanding of aging-mediated changes in mitochondrial
bioenergetics and lipid metabolism that affect T cell function. The bioactive sphingolipid …

Immune nonresponder (INR) HIV-1–infected subjects are characterized by their inability to
reconstitute the CD4+ T cell pool after antiretroviral therapy. This is linked to poor clinical …

To gain understanding on the mechanisms that drive immunosenescence in humans, we
examined CD4+ T cells obtained from younger (20-39 years-old) and older (70+ years-old) …

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is
characterized by alterations of the mitochondrial DNA, reduced respiratory capacity …