[HTML][HTML] The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

[HTML][HTML] Crosstalk between methylation and ncRNAs in breast cancer: therapeutic and diagnostic implications

Y Liu, P Leng, Y Liu, J Guo, H Zhou - International Journal of Molecular …, 2022 - mdpi.com
Breast cancer, as a highly heterogeneous malignant tumor, is one of the primary causes of
death among females worldwide. The etiology of breast cancer involves aberrant epigenetic …

Exposure to ultrafine particulate matter induces NF-κβ mediated epigenetic modifications

A Bhargava, A Shukla, N Bunkar, R Shandilya… - Environmental …, 2019 - Elsevier
Exposure to ultrafine particulate matter (PM0. 1) is positively associated with the etiology of
different acute and chronic disorders; however, the in-depth biological imprints that link …

[HTML][HTML] Epigenetic regulation of MicroRNA clusters and families during tumor development

J Gregorova, P Vychytilova-Faltejskova, S Sevcikova - Cancers, 2021 - mdpi.com
Simple Summary In this review, the history of RNA interference discovery and current
knowledge about microRNA biogenesis and post-transcriptional regulation of gene …

[HTML][HTML] Silencing of long non-coding RNA MIAT sensitizes lung cancer cells to gefitinib by epigenetically regulating miR-34a

Y Fu, C Li, Y Luo, L Li, J Liu, R Gui - Frontiers in pharmacology, 2018 - frontiersin.org
Long non-coding RNA (lncRNA) myocardial infarction associated transcript (MIAT) was
recently identified as oncogene in several cancers. However, the role of MIAT on acquired …

Epigenetic drugs as new emerging therapeutics: What is the scale's orientation of application and challenges?

MR Farani, M Sarlak, A Gholami, M Azaraian… - … -Research and Practice, 2023 - Elsevier
Epigenetics is the study of heritable changes in gene expression or function without altering
the DNA sequence. Important factors are part of epigenetic events, such as methylation …

[HTML][HTML] Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?

C Ma, H Seong, Y Liu, X Yu, S Xu, Y Li - Frontiers in Bioscience …, 2021 - imrpress.com
The epigenetic memory stored in the dynamic modifications, such as base modifications of
cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes …

[PDF][PDF] RETRACTED ARTICLE: Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR …

X Liang, C Xu, X Cao, W Wang - Cancer Management and …, 2019 - Taylor & Francis
Liang X, Xu C, Cao X, Wang W. Cancer Manag Res. 2019; 11: 8923–8936. We, the Editors
and Publisher of Cancer Management and Research, have retracted the following article …

[HTML][HTML] TET enzymes and 5hmC levels in carcinogenesis and progression of breast Cancer: potential therapeutic targets

EG Salmerón-Bárcenas, AE Zacapala-Gómez… - International Journal of …, 2023 - mdpi.com
Breast Cancer (BC) was the most common female cancer in incidence and mortality
worldwide in 2020. Similarly, BC was the top female cancer in the USA in 2022. Risk factors …

[HTML][HTML] Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies

T Aanniz, A Bouyahya, A Balahbib, K El Kadiri… - Chemico-Biological …, 2024 - Elsevier
The regulation of gene expression is fundamental to health and life and is essentially carried
out at the promoter region of the DNA of each gene. Depending on the molecular context …