A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Complement in human disease: approved and up-and-coming therapeutics
EE West, T Woodruff, V Fremeaux-Bacchi, C Kemper - The Lancet, 2023 - thelancet.com
The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …
controller of immune system and tissue homoeostasis. However, dysregulated complement …
Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins
Effective inhibition of the complement system is needed to prevent the accelerated
clearance of nanomaterials by complement cascade and inflammatory responses. Here we …
clearance of nanomaterials by complement cascade and inflammatory responses. Here we …
Combining sandblasting and pink anodisation of Ti implants as a promising method for improving fibroblast adhesion and immune response
C Arias-Mainer, F Romero-Gavilán… - Journal of Materials …, 2024 - pubs.rsc.org
This study examined the effect of combining the sandblasting and anodising of titanium
alloys used in implants on the cell response and protein adsorption patterns. The titanium …
alloys used in implants on the cell response and protein adsorption patterns. The titanium …
Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity
T Tschongov, S Konwar, A Busch, C Sievert… - Frontiers in …, 2024 - frontiersin.org
Most drugs that target the complement system are designed to inhibit the complement
pathway at either the proximal or terminal levels. The use of a natural complement regulator …
pathway at either the proximal or terminal levels. The use of a natural complement regulator …
The complement system: A key player in the host response to infections
A Jayaraman, S Walachowski… - European Journal of …, 2024 - Wiley Online Library
Infections are one of the most significant healthcare and economic burdens across the world
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …
Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro
A Adler, M Fritsch, K Fromell, G Leneweit… - Journal of Materials …, 2023 - pubs.rsc.org
Surface modification with heparin is a powerful biomaterial coating strategy that protects
against innate immunity activation since heparin is a part of the proteoglycan heparan …
against innate immunity activation since heparin is a part of the proteoglycan heparan …