Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a
lysine methyltransferase responsible for the transcriptional activation through lysine 4 of …

DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic
consequences for genome stability if not properly repaired. DSBs can be repaired by either …

Cancer is an important factor threatening human life and health; in recent years, its morbidity
and mortality remain high and demosntrate an upward trend. It is of great significance to …

KDM5B histone demethylase is overexpressed in many cancers and plays an ambivalent
role in oncogenesis, depending on the specific context. This ambivalence could be …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic,
epigenetic, and environmental factors. Recent advance in genomics and epigenetics have …

Although the prevalence of leukemia is increasing, the agents responsible for this increase
are not definitely known. While ionizing radiation (IR) was classified as a group one …

The methylation status of histones plays a crucial role in many cellular processes, including
follicular and oocyte development. Lysine-specific demethylase 2a (KDM2a) has been …

This review discusses the relationship between cellular senescence and radiation exposure.
Given the wide range of ionizing radiation sources encountered by people in professional …

Leber's hereditary optic neuropathy (LHON) is a mitochondrial hereditary disease in which
visual loss affects complex 1 activity of the electron transport chain of mitochondria. It first …