All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …

Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

Research question Which genetic variants might explain the causes of empty follicle
syndrome (EFS) and abnormal zona pellucida (ZP) and affect the success of treatment with …

Background In mammals, normal fertilization depends on the structural and functional
integrity of the zona pellucida (ZP), which is an extracellular matrix surrounding oocytes …

Purpose The aim of this study was to identify the disease-causing mutations found in three
infertile female patients who were diagnosed with abnormal zona pellucida (ZP) and empty …

Background: Empty follicle syndrome (EFS) is defined as the complete failure to retrieve
oocytes after ovarian stimulation. Although several mutations in ZP1, ZP2, ZP3, and LHCGR …

Monospermy occurs in the process of normal fertilization where a single sperm fuses with
the egg, resulting in the formation of a diploid zygote. During the process of fertilization, the …

Genuine empty follicle syndrome (gEFS) is a rare cause of female infertility; it is defined as
the presence of cumulus-oocyte complexes (COCs) in follicular fluid but the absence of …

La zone pellucide (ZP) est une matrice extracellulaire spécifique enveloppant l'ovocyte. Elle
régule la liaison des spermatozoïdes à l'ovocyte lors de la fécondation. Après la …

空卵泡综合征(empty follicle syndrome) 发病机制尚不清楚, 越来越多的研究聚焦于遗传因素,
尤其是调控卵母细胞发育的相关基因. 其中, 透明带糖蛋白1 (zona pellucida glycoprotein 1 …