Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Vitamins are dietary components which are necessary for life. They play a major role in
health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins …

Abstract Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a
calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and …

Homocysteine (Hcy) is a derived sulfur-containing and non-proteinogenic amino acid. The
metabolism of Hcy occurs either through the remethylation to methionine or transsulfuration …

Diabetic Retinopathy (DR), is a significant public health issue and the leading cause of
blindness in working-aged adults worldwide. The vision loss associated with DR affects …

Background Although hyperglycemia is the main instigator in the development of diabetic
retinopathy, elevated circulating levels of a non-protein amino acid, homocysteine, are also …

The disruption of retinal pigment epithelial (RPE) function and the degeneration of
photoreceptors are cardinal features of age related macular degeneration (AMD); however …

Purpose: We recently demonstrated that direct subretinal (SR) injection of adeno-associated
virus (AAV) type 8 (AAV8) into photoreceptor cells and retinal pigment epithelium (RPE) is a …

This study evaluated the effects of elevated homocysteine (Hcy) on the oxidative stress
response in retinal Müller glial cells. Elevated Hcy has been implicated in retinal diseases …