RNA methylation is considered a significant epigenetic modification, a process that does not
alter gene sequence but may play a necessary role in multiple biological processes, such as …

Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and
extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not …

Hepatocellular carcinoma (HCC) is one of the most common malignancies globally, and is
frequently associated with a poor prognosis. 5-methylcytosine (m 5 C) is a common …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high
levels of reactive oxygen species (ROS). ROS levels have been suggested to drive …

Patients with hepatocellular carcinoma (HCC) suffer from few treatment options and poor
survival rates. Here we report that endonuclease VIII-like protein 3 (NEIL3) is overexpressed …

DNA glycosylases are enzymes that initiate the base excision repair pathway, a major
biochemical process that protects the genomes of all living organisms from intrinsically and …

The accumulation of reactive oxygen species (ROS) plays a pivotal role in the development
of various diseases, including cancer. Elevated ROS levels cause oxidative stress, resulting …

Abstract The MTH1 (NUDT1) gene, because it is frequently upregulated in many types of
human cancers, has been considered a general marker of carcinogenesis for over two …

Cancer cells develop protective adaptations against oxidative DNA damage, providing a
strong rationale for targeting DNA repair proteins. There has been a high degree of recent …