In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …

Oligonucleotide gene therapy (OGT) agents (eg antisense, deoxyribozymes, siRNA and
CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs …

Simple Summary Triple-negative breast cancer (TNBC) is an aggressive breast cancer
subtype with poor outcomes and limited therapeutic options. It is characterized by a more …

The introduction of biologically relevant organic moieties in the coordination sphere of
transition metal complexes has recently become a well-established strategy to increase the …

The first concise and efficient synthesis of some fluorine‐containing morpholino nucleosides
has been developed. One synthetic strategy was based on the oxidative ring cleavage of the …

Isomeric compounds are present in the human body as well as in drugs and exhibit different
physiological functions, making their measurement important in clinical science. Isomer …

DNA polymerases are the enzymes able to replicate the genetic information in nucleic acid.
As a result, they are necessary to copy the complete genome of every living creature before …

G protein-coupled receptors (GPCRs) are the major targets of existing drugs for a plethora of
human diseases and dominate the pharmaceutical market. However, over 50% of the …

Compared to traditional small molecule and antibody drugs, RNA‐based drugs offer a
simple design, short research and development cycles, high specificity, broad treatment …

While lipid nanoparticles (LNPs) are a key enabling technology for RNA-based therapeutics,
some outstanding challenges hinder their wider clinical translation and use, particularly in …