The functions and roles of sestrins in regulating human diseases
Y Chen, T Huang, Z Yu, Q Yu, Y Wang, J Hu… - Cellular & Molecular …, 2022 - Springer
Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …
organisms against various noxious stimuli including DNA damage, oxidative stress …
Isorhamnetin: a novel natural product beneficial for cardiovascular disease
WQ Li, J Li, WX Liu, LJ Wu, JY Qin… - Current …, 2022 - ingentaconnect.com
Cardiovascular disease (CVD) has become a severe threat to human beings with increasing
morbidity and mortality. Isorhamnetin (Iso) shows multiple bioactivities, especially in the …
morbidity and mortality. Isorhamnetin (Iso) shows multiple bioactivities, especially in the …
FOXO transcription factors in antioxidant defense
N Krafczyk, LO Klotz - IUBMB life, 2022 - Wiley Online Library
Forkhead box, class O (FOXO) family proteins are widely expressed and highly conserved
transcriptional regulators that modulate cellular fuel metabolism, stress resistance and cell …
transcriptional regulators that modulate cellular fuel metabolism, stress resistance and cell …
SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway
X Yang, P Xue, Z Liu, W Li, C Li, Z Chen - Cellular & molecular biology …, 2022 - Springer
Abstract Background Sestrin2 (SESN2), a stress-inducible protein, has been reported to
protect against denervated muscle atrophy through unfolded protein response and …
protect against denervated muscle atrophy through unfolded protein response and …
Hydroperoxide-reducing enzymes in the regulation of free-radical processes
MG Sharapov, SV Gudkov, VZ Lankin - Biochemistry (Moscow), 2021 - Springer
The review presents current concepts of the molecular mechanisms of oxidative stress
development and describes main stages of the free-radical reactions in oxidative stress …
development and describes main stages of the free-radical reactions in oxidative stress …
Sesamin attenuates PM 2.5-induced cardiovascular injury by inhibiting ferroptosis in rats
J Ren, B Yin, X Li, S Zhu, J Deng, Y Sun, Z Zhang… - Food & Function, 2021 - pubs.rsc.org
Objective: This study aimed to elucidate the pharmacological effects of sesamin (Ses) and its
mechanism of action towards PM2. 5-induced cardiovascular injuries. Method: Forty …
mechanism of action towards PM2. 5-induced cardiovascular injuries. Method: Forty …
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy
Y Bian, C Shi, S Song, L Mu, M Wu, D Qiu… - Cell and Tissue …, 2022 - Springer
Glomerular mesangial cell proliferation and extracellular matrix accumulation contribute to
the progression of diabetic nephropathy (DN). As a conserved stress-inducible protein …
the progression of diabetic nephropathy (DN). As a conserved stress-inducible protein …
Targeting on Nrf2/Sesn2 signaling to rescue cardiac dysfunction during high-fat diet-induced obesity
M Krause-Hauch, J Fedorova, LI Zoungrana, H Wang… - Cells, 2022 - mdpi.com
Obesity is of concern to the population because it is known to cause inflammation and
oxidative stress throughout the body, leading to patient predisposition for health conditions …
oxidative stress throughout the body, leading to patient predisposition for health conditions …
Sestrin2 as a potential target for regulating metabolic-related diseases
L Gong, Z Wang, Z Wang, Z Zhang - Frontiers in Endocrinology, 2021 - frontiersin.org
Sestrin2 is a highly conserved protein that can be induced under a variety of stress
conditions, including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and …
conditions, including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and …
Alarin alleviated cardiac fibrosis via attenuating oxidative stress in heart failure rats
J Li, H Ding, Y Li, H Zhou, W Wang, Y Mei, R Zhang - Amino Acids, 2021 - Springer
The present study was to explore whether alarin could alleviate heart failure (HF) and
attenuate cardia fibrosis via inhibiting oxidative stress. The fibrosis of cardiac fibroblasts …
attenuate cardia fibrosis via inhibiting oxidative stress. The fibrosis of cardiac fibroblasts …