Understanding and predicting the longitudinal course of dementia

RJF Melis, ML Haaksma… - Current opinion in …, 2019 - journals.lww.com
It became clear that dementia progresses very differently, both between and within
individuals. This implies an average trajectory is not informative to individual persons and …

[HTML][HTML] Challenges in predicting cognitive decline in dementia with lewy bodies

K Tsamakis, C Mueller - Dementia and Geriatric Cognitive Disorders, 2021 - karger.com
Despite being the second most common form of neurodegenerative dementia, dementia
with Lewy bodies (DLB) is under-recognized and carries a worse prognosis than other …

Inflammatory biomarkers in newly diagnosed patients with Parkinson disease and related neurodegenerative disorders

CC Pedersen, A Ushakova, RE Skogseth… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Neuroinflammation contributes to Parkinson disease (PD)
pathology, and inflammatory biomarkers may aid in PD diagnosis. Proximity extension assay …

Prodromal dementia with Lewy bodies: clinical characterization and predictors of progression

M van de Beek, I van Steenoven… - Movement …, 2020 - Wiley Online Library
Objective The objective of this study was to examine clinical characteristics, cognitive
decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with …

Neuropsychological impairments and their cognitive architecture in mild cognitive impairment (MCI) with Lewy bodies and MCI-Alzheimer's disease

J Ciafone, A Thomas, R Durcan… - Journal of the …, 2022 - cambridge.org
Objective: The present study aimed to clarify the neuropsychological profile of the emergent
diagnostic category of Mild Cognitive Impairment with Lewy bodies (MCI-LB) and determine …

[HTML][HTML] Discontinuous Galerkin methods for Fisher–Kolmogorov equation with application to α-synuclein spreading in Parkinson's disease

M Corti, F Bonizzoni, AM Quarteroni… - Computer Methods in …, 2023 - Elsevier
This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals
with the numerical modelling of the misfolding process of α-synuclein in Parkinson's …

Clinical trajectories at the End of life in autopsy-confirmed dementia patients with Alzheimer disease and Lewy bodies pathologies

Y Gu, A Kociolek, KK Fernandez, SA Cosentino… - Neurology, 2022 - AAN Enterprises
Background and Objectives Evaluating and understanding the heterogeneity in dementia
course has important implications for clinical practice, health care decision-making, and …

Progression of clinical features in Lewy body dementia can be detected over 6 months

E Matar, SR White, JP Taylor, A Thomas, IG McKeith… - Neurology, 2021 - AAN Enterprises
Objective This study aimed to quantify the trajectory and magnitude of change of the key
clinical features and corresponding symptom domains of dementia with Lewy bodies (DLB) …

Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes

K Wang, C Xu, A Smith, D Xiao, RO Navia, Y Lu… - Progress in Neuro …, 2021 - Elsevier
Abstract Background The Trail Making Test (TMT) Part A (TMT-A) is a good measure of
performance on cognitive processing speed. This study aimed to perform a genome-wide …

Validation of the National Alzheimer's Coordinating Center (NACC) Lewy body disease module neuropsychological tests

A Rahman‐Filipiak, S Sadaghiyani… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction This study assessed the construct validity and clinical utility of the National
Alzheimer's Coordinating Center Lewy Body Dementia (LBD) Module, consisting of the …