Triple negative breast cancer: a mountain yet to be scaled despite the triumphs

Q Wu, S Siddharth, D Sharma - Cancers, 2021 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) is a highly aggressive subtype of
breast cancer that cannot be treated with endocrine therapy and Her2-targeted therapy …

Mitochondrial respiration and energy production under some abiotic stresses

S Aliyari Rad, Z Dehghanian, B Asgari Lajayer… - Journal of Plant Growth …, 2021 - Springer
In plants, mitochondrial respiration supplies energy for biosynthesis, and its equilibrium with
photosynthesis determines the accumulation rate of plant biomass. Though the …

AnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding

L Zheng, S Shi, M Lu, P Fang, Z Pan, H Zhang, Z Zhou… - Genome biology, 2024 - Springer
Protein function annotation has been one of the longstanding issues in biological sciences,
and various computational methods have been developed. However, the existing methods …

Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer

K Lu, Q Chen, M Li, L He, F Riaz, T Zhang… - Free Radical Biology and …, 2020 - Elsevier
Programmed cell death factor 4 (PDCD4) is originally described as a tumor suppressor gene
that exerts antineoplastic effects by promoting apoptosis and inhibiting tumor cell …

DTL is a prognostic biomarker and promotes bladder cancer progression through regulating the AKT/mTOR axis

Y Luo, Z He, W Liu, F Zhou, T Liu… - Oxidative medicine and …, 2022 - Wiley Online Library
Background. Denticleless E3 ubiquitin protein ligase homolog (DTL) has been reported to
be an important regulator for tumorigenesis and progression. Nonetheless, the biological …

Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype

LJ Albrecht, A Höwner, K Griewank… - Clinical and …, 2022 - Wiley Online Library
Background Plasma‐derived tumour‐specific cell‐free nucleic acids are increasingly utilized
as a minimally invasive, real‐time biomarker approach in many solid tumours. Circulating …

[HTML][HTML] Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD4 ubiquitination to regulate the MAPK/JNK pathway

Q Fan, Q Lu, G Wang, W Zhu, L Teng, W Chen… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Salvia miltiorrhiza Bunge and Panax ginseng CA
Meyer have special curative effect on cancer treatment. The optimizing component formula …

Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas

P Zhao, J Cheng, B Li, D Nie, C Li, S Gui… - Cell biology and …, 2021 - Springer
This study explored the function of microRNAs (miRNAs) in invasive pituitary adenomas
(IPA), and developed a microRNA-exosome strategy for the disease treatment. Differentially …

An examination of the anti-cancer properties of plant cannabinoids in preclinical models of mesothelioma

EK Colvin, AL Hudson, LL Anderson, RP Kumar… - Cancers, 2022 - mdpi.com
Simple Summary Mesothelioma is a deadly disease with few treatment options.
Phytocannabinoids derived from the cannabis plant are garnering interest for their anti …

Bioinformatics analysis of the circRNA–miRNA–mRNA network for non-small cell lung cancer

X Cai, L Lin, Q Zhang, W Wu… - Journal of International …, 2020 - journals.sagepub.com
Objective Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung
cancers, but its pathogenesis has not been fully elucidated. Therefore, it is valuable to …