The limitations of many mono-kinase inhibitors can be overcome by agents with multi-target
action. An important advantage of targeting more than one kinase, is an increase in potency …

The recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of
these agents and the importance of the research in the field of angiogenesis inhibitors for …

According to the WHO, cancer caused almost 10 million deaths worldwide in 2020, ie,
almost one in six deaths. Among the most common are breast, lung, colon and rectal and …

High-intensity focused ultrasound (HIFU) can locally ablate biological tissues such as
tumors, ie, induce their rapid heating and coagulative necrosis without causing damage to …

Benzimidazole is a common kinase inhibitor scaffold and benzimidazole-based compounds
interact with enzymes by multiple binding modes. In some cases, the benzimidazole acts as …

Langerhans cell histiocytosis is a rare disorder of Langerhans cells, a component of the
dendritic cell system, with an unknown pathogenesis. Conventional therapy for patients with …

Since the introduction of chemotherapy in cancer therapy, development of resistance to
every new therapeutic has been the universal experience. The growing understanding of …

Prostate cancer is the most prevalent tumor in the male population and the second leading
cause of cancerrelated death in men in Western countries. Besides genetic and epigenetic …

Leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) is a multifunctional
protein involved in the mitochondrial gene expression and function, cell cycle progression …

Tumors of various etiology are considered to be one of the most frequent reasons for
disorders and death. According to the WHO, cancer is a leading cause of death accounting …