The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

Undoubtedly, the food intake process is one of the most necessary physiological functions
for the survival of animals and humans. Although; this operation seems simple on the …

The gut microbiome modulates neurochemical function and behavior and has been
implicated in numerous central nervous system (CNS) diseases, including developmental …

Abstract Background and Hypotheses Weight gain and adverse cardiometabolic effects
often limit the clinical utility of olanzapine. In ENLIGHTEN-2, combining olanzapine with the …

The opioid receptors (OR) regulate food intake. Still, despite extensive pre-clinical research,
the overall effects and individual contribution of the mu (MOR), kappa (KOR), and delta …

The κ‑opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role
in the regulation of pain, anesthesia, addiction and other pathological and physiological …

Obesity is a growing global epidemic that stems from the increasing availability of highly-
palatable foods and the consequent enhanced calorie consumption. Extensive research has …

The mu-opioid receptor (MOR, OPRM1) has important roles in diverse functions including
reward, addiction, and response to pain treatment. SNP rs1799971 (118A> G, N40D) which …

Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH)
are a diverse group of neurons that project widely to different brain regions. It is unknown …

Objectives: We have previously shown that the combined consumption of fat and a sucrose
solution induces overeating, and there is evidence indicating that sucrose drinking directly …