Lutein with various therapeutic activities based on micro and nanoformulations: A systematic mini-review

M Maghsoudloo… - Micro Nano Bio …, 2023 - mnba-journal.com
Lutein is a carotenoid with reported anticancer, antibacterial, anticancer,
antineurodegenerative, and anti-inflammatory activities. In addition, this bioactive …

Melatonin as an add-on treatment for epilepsy: A systematic review and meta-analysis

Z Liu, J Zhu, Z Shen, Y Ling, Y Zeng, Y Yang… - … : European Journal of …, 2024 - Elsevier
Purpose Epilepsy, one severe prevalent brain disorder, primarily relies on drug treatment.
However, approximately one-third of patients with epilepsy do not achieve effective control …

Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies

A Rajput, P Sharma, N Kumar, H Singh, T Singh… - Metabolic Brain …, 2023 - Springer
Epilepsy, a chronic neurological condition, impacts millions of individuals globally and
remains a significant contributor to both illness and mortality. Available antiepileptic drugs …

[HTML][HTML] Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1 …

MM Almostafa, ME Mohamed, NS Younis - International …, 2024 - Elsevier
Background Epilepsy is a severe neurological disorder associated with substantial morbidity
and mortality. Vanillin (Van) is a natural phenolic aldehyde with beneficial pharmacological …

[HTML][HTML] Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of …

N Perveen, F Alqahtani, W Ashraf, MF Rasool… - Saudi Pharmaceutical …, 2024 - Elsevier
Abstract Perampanel (PER), a novel 3rd-generation antiseizure drug that modulates altered
post-synaptic glutamatergic storming by selectively inhibiting AMPA receptors, is recently …

[HTML][HTML] Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

MF Hammer, CT Krzyzaniak, E Bahramnejad… - Clinical …, 2024 - portlandpress.com
Background: Epilepsy is a common neurological disease; however, few if any of the
currently marketed antiseizure medications prevent or cure epilepsy. Discovery of …

Advances in nanomedicines: a promising therapeutic strategy for ischemic cerebral stroke treatment

J Li, F Xie, X Ma - Nanomedicine, 2024 - Taylor & Francis
Ischemic stroke, prevalent among the elderly, necessitates attention to reperfusion injury
post treatment. Limited drug access to the brain, owing to the blood–brain barrier, restricts …

Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease …

R Hameed, A Naseer, A Saxena, M Akbar… - Cellular and Molecular …, 2024 - Springer
Glial cells constitute nearly half of the mammalian nervous system's cellular composition.
The glia in C. elegans perform majority of tasks comparable to those conducted by their …

Evaluation of bioactive potentials in the crude flavonoid fraction from the leaves of Butea monosperma in vitro and in vivo in experimental models

R Bala, S Mehta, VC Roy, RC Roy, S Roy… - Indian Journal of …, 2023 - or.niscpr.res.in
Oxidative stress is responsible for the advent of seizure hence, antioxidants are used for the
treatment neurodegenerative ailments such as epilepsy. Profoundly, Butea monosperma …

Therapeutic potential of thymoquinone and its nanoformulations in neuropsychological disorders: a comprehensive review on molecular mechanisms in preclinical …

M Saadat, N Dahmardeh, F Sheikhbahaei… - Naunyn-Schmiedeberg's …, 2023 - Springer
Thymoquinone (THQ) and its nanoformulation (NFs) have emerged as promising candidates
for the treatment of neurological diseases due to their diverse pharmacological properties …