Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Most physiological functions originate with the communication between organs. Mouse
genetics has revived this holistic view of physiology through the identification of inter-organ …

Background Skeletal muscle is a plastic tissue that adapts to changes in exercise, nutrition,
and stress by secreting myokines and myometabolites. These muscle‐secreted factors have …

Skeletal muscle is a highly vascularized tissue that can secrete proteins called myokines.
These muscle-secreted factors exert biological functions in muscle itself (autocrine effect) or …

Studies in mammals and Drosophila have demonstrated the existence and significance of
secreted factors involved in communication between distal organs. In this review, primarily …

Highlights•The function of the autophagy/lysosome system declines during skeletal muscle
aging.•Boosting basal autophagy protects from sarcopenia.•Autophagy inhibition impedes …