Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …

Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …

Autophagy captures intracellular components and delivers them to lysosomes, where they
are degraded and recycled to sustain metabolism and to enable survival during starvation …

Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and
resistance to anti-cancer therapy, leading to an overall poor prognosis. Despite continued …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a 5-year
survival rate of< 10%. The tumour microenvironment (TME) of PDAC is characterized by …

Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic
constituents to sustain cellular and mammalian metabolism and survival during starvation …

Autophagy in Human Diseases Autophagy is a complex process of intracellular degradation
of senescent or malfunctioning organelles. Dysregulated autophagy is associated with …