Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …

Lysosomes degrade macromolecules and recycle their nutrient content to support cell
function and survival. However, the machineries involved in lysosomal recycling of many …

Autophagy is intricately linked with many intracellular signaling pathways, particularly
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal …

Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of
cancer therapy. However, components of canonical autophagy play roles in other biological …

Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised
of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have …

Pancreatic cancer (PDAC) is one of the deadliest types of human cancers, owing to late
stage at presentation and pervasive therapeutic resistance. The extensive tumour …

Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a
ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple …

Pancreatic ductal adenocarcinoma (PDAC) cells require substantial metabolic rewiring to
overcome nutrient limitations and immune surveillance. However, the metabolic pathways …

As one of the two highly conserved cellular degradation systems, autophagy plays a critical
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …