Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to
the current standards of care. The difficulty in treating this disease is due to a number of …

Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic
cells, explaining why both normal and malignant cells benefit from proficient autophagic …

Autophagy and glycolysis are highly conserved biological processes involved in both
physiological and pathological cellular programs, but the interplay between these processes …

Autophagy supports the fast growth of established tumors and promotes tumor resistance to
multiple treatments. Inhibition of autophagy is a promising strategy for tumor therapy …

Autophagy, a lysosomal catabolic process, involves degradation of cellular materials,
protein aggregate, and dysfunctional organelles to maintain cellular homeostasis. Strikingly …

Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides
providing energy and building blocks during starvation via random degradation, autophagy …

Devimistat (CPI-613®) is a novel lipoate analog that inhibits the tricarboxcylic acid cycle at
two key carbon entry points. Through its inhibition of pyruvate dehydrogenase and a …

Loss of tumor suppressor liver kinase B1 (LKB1) promotes cancer cell proliferation but also
leads to decreased metabolic plasticity in dealing with energy crises. Autophagy is a …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …

While autophagy is thought to be an essential process in some cancer cells, it is unknown if
or how such cancer cells can circumvent autophagy inhibition. To address this, we …