Immunotherapies such as CAR-T cell transfer and antibody-targeted therapy have produced
promising clinical outcomes in patients with advanced and metastatic cancer that are …

Autophagy is a conserved catabolic process that maintains cellular homeostasis. Autophagy
supports lung tumorigenesis and is a potential therapeutic target in lung cancer. A better …

Autophagy is a critical regulator of cellular survival, differentiation, development, and
homeostasis, dysregulation of which is associated with diverse diseases including cancer …

Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for
the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell …

The clinical significance of gene fusions detected by DNA-based next generation
sequencing remains unclear as resistance mechanisms to EGFR tyrosine kinase inhibitors …

Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell
and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and …

Autophagy is an important cellular degradation pathway with a central role in metabolism as
well as basic quality control, two processes inextricably linked to ageing. A decrease in …

Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy.
Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to …

Pancreatic cancer is a devastating disease with poor prognosis in the modern era.
Inflammatory processes have emerged as key mediators of pancreatic cancer development …

Autophagy is a catabolic process that captures cellular waste and degrades them in the
lysosome. The main functions of autophagy are quality control of cytosolic proteins and …