Pancreatic ductal adenocarcinoma (PDAC) is characterized by its highly reactive
inflammatory desmoplastic stroma with evidence of an extensive tumor stromal interaction …

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly
cancer by 2040, owing to the high incidence of metastatic disease and limited responses to …

Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute
about 6% of head and neck cancer diagnoses based on estimate by American Head and …

Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic
components are captured in the autophagosome and degraded in the lysosome. Autophagy …

In cancer therapy, a principle goal is to kill cancer cells while minimizing death of normal
cells. Traditional cytotoxic therapies and the newer agents that target specific signaling …

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …

Metabolic reprogramming is a feature of cancers for which recent research has been
particularly active, providing numerous insights into the mechanisms involved. It occurs …

Neuroblastoma is the most common extracranial solid malignancy in the pediatric
population, accounting for over 9% of all cancer-related deaths in children. Autophagy is a …

Autophagy is a universal cellular homeostatic process, required for the clearance of
dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell …

Autophagy is an evolutionarily conserved lysosomal-dependent pathway for degrading
cytoplasmic proteins, macromolecules, and organelles. Autophagy-related genes (Atgs) are …