Over the last two decades, the rapidly expanding field of tumor metabolism has enhanced
our knowledge of the impact of nutrient availability on metabolic reprogramming in cancer …

Evading immune destruction is one of the hallmarks of cancer. A key mechanism of immune
evasion deployed by tumour cells is to reduce neoantigen presentation through down …

Despite conventional treatment options including chemoradiation, patients with the most
aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average …

Pancreatic cancer is amongst the most lethal malignancies, while its poor prognosis could
be associated with promotion of autophagy and the tumor immune microenvironment …

Background Autophagy plays an important role in tumour cell growth and survival and also
promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer …

The incidence of pancreatic cancer is increasing in both developed and developing Nations.
In recent years, various research evidence suggested that reprogrammed metabolism may …

The lysosome is an essential catabolic organelle that consumes cellular biomass to
regenerate basic building blocks that can fuel anabolic reactions. This simple view has …

Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …

Autophagy is well-known as an internal catabolic process that is evolutionarily conserved
and performs the key biological function in maintaining cellular homeostasis. It is tightly …

Simple Summary Metabolic heterogeneity and mitochondrial function are important
parameters that might influence therapeutic vulnerabilities and predict the clinical outcomes …