Diverse cellular roles of autophagy
H Morishita, N Mizushima - Annual review of cell and …, 2019 - annualreviews.org
Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …
materials to lysosomes via autophagosomes. Recent advances have enabled identification …
A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 …
C Zhou, C Yi, Y Yi, W Qin, Y Yan, X Dong, X Zhang… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety
of cytoplasmic materials are delivered to lysosomes and eventually degraded. However …
of cytoplasmic materials are delivered to lysosomes and eventually degraded. However …
Molecular logic of mTORC1 signalling as a metabolic rheostat
AJ Valvezan, BD Manning - Nature metabolism, 2019 - nature.com
The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …
as a key conduit between growth signals and the metabolic processes underlying cell …
RNA transport and local translation in neurodevelopmental and neurodegenerative disease
MS Fernandopulle, J Lippincott-Schwartz… - Nature …, 2021 - nature.com
Neurons decentralize protein synthesis from the cell body to support the active metabolism
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus …
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus …
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions
MA Bakowski, N Beutler, KC Wolff… - Nature …, 2021 - nature.com
The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug …
2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug …
Autophagy in aging and longevity
SQ Wong, AV Kumar, J Mills, LR Lapierre - Human genetics, 2020 - Springer
Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …
grown remarkably in the last two decades. Early work established autophagy as a general …
Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
L Zhu, Y Zhu, S Han, M Chen, P Song, D Dai… - Cell death & …, 2019 - nature.com
Chemoresistance remains the uppermost disincentive for cancer treatment on account of
many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging …
many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging …
Roles of RNA modifications in diverse cellular functions
Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The
deposition and function of these modifications are mediated by the actions of writer, reader …
deposition and function of these modifications are mediated by the actions of writer, reader …