In the last decade, uremic toxicity as a potential cause for the excess of cardiovascular
disease and mortality observed in chronic kidney disease gained more and more interest …

Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23
inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in …

Abstract Rationale & Objective Vitamin D is widely used to manage chronic kidney disease-
mineral and bone disorder (CKD-MBD). We aimed to evaluate the effects of vitamin D …

Recent studies of inherited disorders of phosphate metabolism have shed new light on the
understanding of phosphate metabolism. Phosphate has important functions in the body and …

Context: Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin
D metabolism. Circulating FGF23 levels are elevated in inherited and acquired …

Longitudinal studies testing the relationship between repeated measures of vitamin D or
fibroblast growth factor 23 (FGF23) and infectious and cardiac hospitalizations and death in …

Objective—Disturbances in mineral metabolism define an increased cardiovascular risk in
patients with chronic kidney disease. Fibroblast growth factor-23 (FGF23) is a circulating …

Background Cardiac troponin T is independently associated with cardiovascular events and
mortality in patients with chronic kidney disease (CKD). Serum levels of high sensitivity …

Background. High levels of the phosphaturic hormone fibroblast growth factor 23 (FGF-23)
predict mortality in haemodialysis patients. The prognostic relevance of increased plasma …

Patients with chronic kidney disease (CKD) are prone to developing cardiac hypertrophy
and fibrosis, which is associated with increased fibroblast growth factor 23 (FGF23) serum …