The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

We are entering a new era in genomics where entire centromeric regions are accurately
represented in human reference assemblies. Access to these high-resolution maps will …

Chromosome inheritance depends on centromeres, epigenetically specified regions of
chromosomes. While conventional human centromeres are known to be built of long tandem …

Centromere positioning and organization are crucial for genome evolution; however,
research on centromere biology is largely influenced by the quality of available genome …

Repeat sequences account for over half of the human genome and represent a significant
source of variation that underlies physiological and pathological states. Yet, their study has …

Satellite DNA sequences are an integral part of centromeres, regions critical for faithful
segregation of chromosomes during cell division. Because of their complex repetitive …

Centromeres play a key role in the maintenance of genome stability to prevent
carcinogenesis and diseases. They are specialized chromosome loci essential to ensure …

Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Centromeres connect chromosomes and spindle microtubules to ensure faithful
chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA …

Maintenance of genome stability relies on functional centromeres for correct chromosome
segregation and faithful inheritance of the genetic information. The human centromere is the …