Sickle cell disease (SCD) is a severe, multisystemic hematological disorder that impacts
nearly every major organ in adults. The current approved treatments for SCD directly target …

Sickle cell disease is a hemoglobinopathy resulting from a point mutation from glutamate to
valine at position six of the β‐globin chains of hemoglobin. This mutation gives rise to …

Sickle cell disease (SCD) is one of the most common and clinically severe inherited
diseases in the world, estimated to affect at least 3 to 6 million people. Greater than 90% of …

Hemoglobin and Hemoglobinologists This volume, Hemoglobin Disorders: Molecular
Methods and Protocols, will be introduced with a review of the great milestones in the field …

US10836771B2 - Compositions for activating pyruvate kinase - Google Patents US10836771B2
- Compositions for activating pyruvate kinase - Google Patents Compositions for activating …

The mutation of β6 from glu to val in hemoglobin is responsible for the polymer formation
that leads to vaso-occlusion, and a range of severe consequences in sickle cell disease …

Background: Moringa oleifera Lam.(Moringaceae) cultivated in South West Nigeria has
been used locally in the treatment of iron deficiency anaemia, and especially in the …

One mechanism by which nitric oxide (NO) has been proposed to benefit patients with sickle
cell disease is by reducing intracellular polymerization of sickle hemoglobin (HbS). In this …

Understanding the physical basis of protein aggregation covers strong physical and
biomedical interests. Sickle hemoglobin (HbS) is a point‐mutant form of normal human adult …

A new calorimetric technique is described which allows the measurement of metabolic heat
rates in biological materials which are triggered by changes in the oxygen tension. It uses …