[HTML][HTML] Genetics of type 2 diabetes
Since early 2007, the establishment of international consortia and biobanks has catalyzed
the performance of large-scale genomic studies. These efforts have driven an explosion in …
the performance of large-scale genomic studies. These efforts have driven an explosion in …
The missing heritability in type 1 diabetes
H Pang, J Lin, S Luo, G Huang, X Li… - Diabetes, Obesity and …, 2022 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is a complex autoimmune disease characterized by an
absolute deficiency of insulin. It affects more than 20 million people worldwide and imposes …
absolute deficiency of insulin. It affects more than 20 million people worldwide and imposes …
Association and interaction of genetics and area-level socioeconomic factors on the prevalence of type 2 diabetes and obesity
OBJECTIVE Quantify the impact of genetic and socioeconomic factors on risk of type 2
diabetes (T2D) and obesity. RESEARCH DESIGN AND METHODS Among participants in …
diabetes (T2D) and obesity. RESEARCH DESIGN AND METHODS Among participants in …
A polygenic score method boosted by non-additive models
Dominance heritability in complex traits has received increasing recognition. However, most
polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present …
polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present …
FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies
Background Asthma is a heterogeneous common respiratory disease that remains poorly
understood. The established genetic associations fail to explain the high estimated …
understood. The established genetic associations fail to explain the high estimated …
Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations
Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
Using GWAS summary data to impute traits for genotyped individuals
Genome-wide association study (GWAS) summary data have become extremely useful in
daily routine data analysis, largely facilitating new methods development and new …
daily routine data analysis, largely facilitating new methods development and new …
Shared Genetic Architectures between Coronary Artery Disease and Type 2 Diabetes Mellitus in East Asian and European Populations
X Li, Z Zhou, Y Ma, K Ding, H Xiao, D Chen, N Liu - Biomedicines, 2024 - mdpi.com
Coronary artery disease (CAD) is a common comorbidity of type 2 diabetes mellitus (T2DM).
However, the pathophysiology connecting these two phenotypes remains to be further …
However, the pathophysiology connecting these two phenotypes remains to be further …
[HTML][HTML] Influence of autozygosity on common disease risk across the phenotypic spectrum
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative
traits. We investigated associations between the fraction of the genome in runs of …
traits. We investigated associations between the fraction of the genome in runs of …
Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity
Genetic association studies have focused on testing additive models in cohorts with
European ancestry. Little is known about recessive effects on common diseases, specifically …
European ancestry. Little is known about recessive effects on common diseases, specifically …