DNA adduct profiling of in vitro colonic meat digests to map red vs. white meat genotoxicity

LY Hemeryck, C Rombouts, E De Paepe… - Food and chemical …, 2018 - Elsevier
The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk.
One of the major hypotheses states that heme iron (present in red meat) stimulates the …

Liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced DNA adducts in mammalian cells

J Leng, Y Wang - Analytical chemistry, 2017 - ACS Publications
Quantification of DNA lesions constitutes one of the main tasks in toxicology and in
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …

Computational risk assessment framework for the hazard analysis of bisphenols and quinone metabolites

S Pandit, P Singh, R Parthasarathi - Journal of Hazardous Materials, 2022 - Elsevier
Bisphenol A (BPA) is a widely used chemical in plastics but its proven harmful effects has
led to the replacement and production of its analogs that might also induce hazard as well …

Adductomic screening of hemoglobin adducts and monitoring of micronuclei in school-age children

H Carlsson, J Aasa, N Kotova, D Vare… - Chemical research in …, 2017 - ACS Publications
Electrophilic compounds/metabolites present in humans, originating from endogenous
processes or exogenous exposure, pose a risk to health effects through their reactions with …

[HTML][HTML] Strategy for identifying unknown hemoglobin adducts using adductome LC-MS/MS data: Identification of adducts corresponding to acrylic acid, glyoxal …

H Carlsson, M Törnqvist - Food and Chemical Toxicology, 2016 - Elsevier
Electrophilic compounds have the ability to form adducts with nucleophilic sites in proteins
and DNA in tissues, and thereby constitute risks for toxic effects. Adductomic approaches are …

Hemoglobin adducts and urinary metabolites of arylamines and nitroarenes

G Sabbioni - Chemical Research in Toxicology, 2017 - ACS Publications
Arylamines and nitroarenes are intermediates in the production of pharmaceuticals, dyes,
pesticides, and plastics and are important environmental and occupational pollutants. N …

In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line

T Takeshita, RA Kanaly - Frontiers in Chemistry, 2019 - frontiersin.org
In the development of new chemical substances, genetic toxicity evaluations are a high
priority for safety risk management. Evaluation of the possibility of compound carcinogenicity …

Nanoscale battery cathode materials induce DNA damage in bacteria

TA Qiu, V Guidolin, KNL Hoang, T Pho, PW Villalta… - Chemical …, 2020 - pubs.rsc.org
The increasing use of nanoscale lithium nickel manganese cobalt oxide (LixNiyMnzCo1− y−
zO2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment …

Is high resolution a strict requirement for mass spectrometry-based cellular DNA adductomics?

YJ Chang, MS Cooke, YR Chen, SF Yang, PS Li… - Chemosphere, 2021 - Elsevier
Exposure to endogenous and exogenous factors can result in the formation of a wide variety
of DNA adducts, and these may lead to gene mutations, thereby contributing to the …

Development of a targeted method for DNA adductome and its application as sensitive biomarkers of ambient air pollution exposure

R Xu, Y Zhang, Y Gao, S Jia, S Choi, Y Xu… - Journal of Hazardous …, 2024 - Elsevier
DNA adducts are widely recognized as biomarkers of exposure to environmental
carcinogens and associated health effects in toxicological and epidemiological studies. This …