Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
The contribution of the exposome to the burden of cardiovascular disease
Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …
the Global Burden of Disease project, indicate that chronic non-communicable diseases …
Levels of polycyclic aromatic hydrocarbons in the water and sediment of Buffalo River Estuary, South Africa and their health risk assessment
The incidence and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in the
Buffalo River Estuary in the Eastern Cape Province of South Africa were assessed in this …
Buffalo River Estuary in the Eastern Cape Province of South Africa were assessed in this …
Risk determination and prevention of breast cancer
Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …
made in the treatment of breast cancer, but the introduction of methods to predict women at …
Polycyclic aromatic hydrocarbons and PAH-related DNA adducts
B Ewa, MŠ Danuta - Journal of applied genetics, 2017 - Springer
Investigations on the impact of chemicals on the environment and human health have led to
the development of an exposome concept. The exposome refers to the totality of exposures …
the development of an exposome concept. The exposome refers to the totality of exposures …
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
Antioxidants and HNE in redox homeostasis
W Łuczaj, A Gęgotek, E Skrzydlewska - Free Radical Biology and Medicine, 2017 - Elsevier
Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …
which is maintained by the balance between continuous ROS/RNS generation and several …
Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
Applications of fourier transform ion cyclotron resonance (FT-ICR) and orbitrap based high resolution mass spectrometry in metabolomics and lipidomics
Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major
approaches aimed at understanding the organization and dynamics of metabolic networks …
approaches aimed at understanding the organization and dynamics of metabolic networks …
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …