Despite the advancement in medicine, management of heart failure (HF), which usually
presents as a disease syndrome, has been a challenge to healthcare providers. This is …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Hyponatremia is a serious, but often overlooked, electrolyte imbalance that has been
independently associated with a wide range of deleterious changes involving many different …

Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Pirfenidone (PFD) is a pharmacological compound with therapeutic efficacy in idiopathic
pulmonary fibrosis. It has been chiefly characterized as an antifibrotic agent, although it was …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

Heart failure (HF) is a major cause of morbidity and mortality in the Western world. HF is
present in more than 5 million people in the United States, accounting for nearly US $40 …

Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-
fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression …

1022 Circulation August 27, 2013 dehydrogenase activity. 14 Increases in cardiac
aldosterone have been reported in experimental models of myocardial infarction, 15 …

MicroRNAs (miRNAs) are emerging as key control molecules in the regulation of gene
expression, and their role in heart disease is becoming increasingly evident. Given the …