The IL-33/ST2 L signaling pathway is involved in the pathophysiological processes of
several diseases and mainly exerts anti-inflammatory and antifibrotic effects. Soluble …

Inflammation plays an important role in the development of heart failure (HF) after
myocardial infarction (MI). Suppression of post-infarction inflammatory cascade has become …

Sacubitril/Valsartan, proved superiority over other conventional heart failure management
treatments, but its mechanisms of action remains obscure. In this study, we sought to explore …

To realize human induced pluripotent stem cell (hiPSC)-based cardiac regenerative therapy,
evidence of therapeutic advantages in human-sized diseased hearts are indispensable. In …

Background Oxidative stress is an important factor involved in the progress of heart failure.
The current study was performed to investigate whether pinocembrin was able to ameliorate …

Sodium–glucose cotransporter 2 (SGLT2) inhibitors such as empagliflozin are known to
reduce the risk of hospitalizations related to heart failure irrespective of diabetic state …

Inflammasomes are a group of multiprotein signaling complexes located in the cytoplasm.
Several inflammasomes have been identified, including NLRP1, NLRP2, NLRP3, AIM2, and …

Methods and Results: Of the total population of 13,104 consecutive AMI patients enrolled in
the KAMIR-NIH, the current study analyzed 11,909 patients. These patients were classified …

Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative
medicine, and tissue engineering. Due to their secretory functions, differentiation …

Cardiac fibrosis and myocyte hypertrophy play contributory roles in the progression of
diseases such as heart Failure (HF) through what is collectively termed cardiac remodelling …