The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Vitamin B12 is assimilated and transported by complex mechanisms that involve three
transport proteins, intrinsic factor (IF), haptocorrin (HC) and transcobalamin (TC) and their …

Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity,
large number and modest effect sizes of associated variants on disease risk and the …

Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

The ability to take up substances from the surrounding environment not only provides cells
with vital nutrients, but also enables the selective transport of substances from one …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …