▪ Abstract Albumin is the most abundant protein in serum and contributes to the maintenance
of oncotic pressure as well as to transport of hydrophobic molecules. Although albumin is a …

BACKGROUND: Vitamin B12 (cobalamin) is a cobalt-containing compound synthesized by
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption …

Derivatives of cobalamin (vitamin B12) are required for activity of two enzymes in humans.
Adenosylcobalamin is required for activity of mitochondrial methylmalonylCoA mutase and …

Proteins filtered in renal glomeruli are removed from the tubular fluid by endocytosis in the
proximal tubule mediated by the two receptors megalin and cubilin. After endocytic uptake …

Cubilin is the intestinal receptor for the endocytosis of intrinsic factor–vitamin B 12. However,
several lines of evidence, including a high expression in kidney and yolk sac, indicate it may …

This paper provides a general review on folate and vitamin B12 nutrition and metabolism
and the metabolic interrelationship between these vitamins. The effects of some common …

Biochemical and physiological processes that underlie the mechanism of albuminuria are
completely reassessed in this article in view of recent discoveries that filtered proteins …

Optimal functioning of the central and peripheral nervous system is dependent on a constant
supply of appropriate nutrients. Particularly important for optimal functioning of the nervous …

Low plasma B-vitamin levels and elevated homocysteine have been associated with cancer,
cardiovascular disease and neurodegenerative disorders. Common variants in FUT2 on …

▪ Abstract Polarized epithelia have several functional and morphological similarities,
including a high capacity for uptake of various substances present in the fluids facing the …