The tinker, tailor, soldier in intracellular B12 trafficking
The recognition of eight discrete genetic complementation groups among patients with
inherited cobalamin disorders provided early insights into the complexity of a cofactor …
inherited cobalamin disorders provided early insights into the complexity of a cofactor …
The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells
S De, S Kuwahara, A Saito - Membranes, 2014 - mdpi.com
Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important
for the reabsorption and metabolization of proteins and other substances, including carrier …
for the reabsorption and metabolization of proteins and other substances, including carrier …
Acquired and inherited disorders of cobalamin and folate in children
V Michael Whitehead - British journal of haematology, 2006 - Wiley Online Library
Cobalamin deficiency in the newborn usually results from cobalamin deficiency in the
mother. Megaloblastic anaemia, pancytopenia and failure to thrive can be present …
mother. Megaloblastic anaemia, pancytopenia and failure to thrive can be present …
Protein reabsorption in renal proximal tubule—function and dysfunction in kidney pathophysiology
EI Christensen, J Gburek - Pediatric nephrology, 2004 - Springer
The endocytic receptors megalin and cubilin are highly expressed in the early parts of the
endocytic apparatus of the renal proximal tubule. The two receptors appear to be …
endocytic apparatus of the renal proximal tubule. The two receptors appear to be …
Imerslund-Gräsbeck syndrome (selective vitamin B12 malabsorption with proteinuria)
R Gräsbeck - Orphanet journal of rare diseases, 2006 - Springer
Imerslund-Gräsbeck syndrome (IGS) or selective vitamin B 12 (cobalamin) malabsorption
with proteinuria is a rare autosomal recessive disorder characterized by vitamin B 12 …
with proteinuria is a rare autosomal recessive disorder characterized by vitamin B 12 …
The Finnish disease heritage III: the individual diseases
R Norio - Human genetics, 2003 - Springer
This article is the third and last in a series entitled The Finnish Disease Heritage I–III. All the
36 rare hereditary diseases belonging to this entity are described for clinical and molecular …
36 rare hereditary diseases belonging to this entity are described for clinical and molecular …
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin
J Gburek, PJ Verroust, TE Willnow… - Journal of the …, 2002 - journals.lww.com
The kidney is the main site of hemoglobin clearance and degradation in conditions of severe
hemolysis. Herein it is reported that megalin and cubilin, two epithelial endocytic receptors …
hemolysis. Herein it is reported that megalin and cubilin, two epithelial endocytic receptors …
The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells
AE Perez Bay, R Schreiner, I Benedicto… - Nature …, 2016 - nature.com
The basolateral recycling and transcytotic pathways of epithelial cells were previously
defined using markers such as transferrin (TfR) and polymeric IgA (pIgR) receptors. In …
defined using markers such as transferrin (TfR) and polymeric IgA (pIgR) receptors. In …
[HTML][HTML] The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology
PJ Verroust, H Birn, R Nielsen, R Kozyraki… - Kidney international, 2002 - Elsevier
The tandem endocytic receptors megalin and cubilin are important proteins in renal
pathology. The molecular mechanisms controlling proximal tubule reabsorption of proteins …
pathology. The molecular mechanisms controlling proximal tubule reabsorption of proteins …
Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
SM Hammad, JL Barth, C Knaak… - Journal of Biological …, 2000 - ASBMB
Cubilin has recently been shown to function as an endocytic receptor for high density
lipoproteins (HDL). The lack of apparent transmembrane and cytoplasmic domains in cubilin …
lipoproteins (HDL). The lack of apparent transmembrane and cytoplasmic domains in cubilin …