HDL: the metabolism, function, and therapeutic importance
M Wang, MR Briggs - Chemical reviews, 2004 - ACS Publications
Epidemiological studies point to an inverse relationship between high-density lipoprotein
(HDL) levels and the risk of coronary artery disease (CAD). 1-5 Clinical trials such as the …
(HDL) levels and the risk of coronary artery disease (CAD). 1-5 Clinical trials such as the …
The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins
H Birn - American Journal of Physiology-Renal Physiology, 2006 - journals.physiology.org
Over the past 10 years, animal studies have uncovered the molecular mechanisms for the
renal tubular recovery of filtered vitamin and vitamin carrier proteins. Relatively few …
renal tubular recovery of filtered vitamin and vitamin carrier proteins. Relatively few …
Structural basis for receptor recognition of vitamin-B12–intrinsic factor complexes
Abstract Cobalamin (Cbl, vitamin B12) is a bacterial organic compound and an essential
coenzyme in mammals, which take it up from the diet. This occurs by the combined action of …
coenzyme in mammals, which take it up from the diet. This occurs by the combined action of …
Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
SM Tanner, M Aminoff, FA Wright, S Liyanarachchi… - Nature …, 2003 - nature.com
The amnionless gene, Amn, on mouse chromosome 12 encodes a type I transmembrane
protein that is expressed in the extraembryonic visceral layer during gastrulation. Mice …
protein that is expressed in the extraembryonic visceral layer during gastrulation. Mice …
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo
Q He, M Madsen, A Kilkenney, B Gregory… - Blood, 2005 - ashpublications.org
Amnionless (AMN) and cubilin gene products appear to be essential functional subunits of
an endocytic receptor called cubam. Mutation of either gene causes autosomal recessive …
an endocytic receptor called cubam. Mutation of either gene causes autosomal recessive …
Proteinuria and events beyond the slit
R Nielsen, EI Christensen - Pediatric nephrology, 2010 - Springer
The origin of proteinuria is found in either the glomerular filtration device or the proximal
tubular reabsorption machinery. During equilibrium, small amounts of predominantly low …
tubular reabsorption machinery. During equilibrium, small amounts of predominantly low …
Bladder augmentation and urinary diversion in patients with neurogenic bladder: non-surgical considerations
R Stein, A Schröder, JW Thüroff - Journal of pediatric urology, 2012 - Elsevier
Segments from almost all parts of the bowel have been used for urinary diversion. As a
result, the available absorptive surface area of the bowel is reduced, and the incorporation …
result, the available absorptive surface area of the bowel is reduced, and the incorporation …
Cobalamin (vitamin B12) in subacute combined degeneration and beyond: traditional interpretations and novel theories
G Scalabrino - Experimental neurology, 2005 - Elsevier
Subacute combined degeneration (SCD) is a neuropathy due to cobalamin (Cbl)(vitamin
B12) deficiency acquired in adult age. Hitherto, the theories advanced to explain the …
B12) deficiency acquired in adult age. Hitherto, the theories advanced to explain the …
An update on vitamin B12-related gene polymorphisms and B12 status
Background Vitamin B12 is an essential micronutrient in humans needed for health
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …
Molecular mechanisms of receptor‐mediated endocytosis in the renal proximal tubular epithelium
A Saito, H Sato, N Iino, T Takeda - BioMed Research …, 2010 - Wiley Online Library
Receptor‐mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells
(PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances …
(PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances …