Cubilin and megalin are multifunctional endocytotic receptors expressed in many absorptive
epithelia. The receptors have separate functions but may act in concert in several tissues …

Cubilin, a 456 kDa multipurpose receptor lacking in both transmembrane and cytoplasmic
domains is expressed in the apical BBMs (brush border membranes) of polarized epithelia …

Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein
receptor family that displays a large luminal domain with multiligand binding properties …

Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor
serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic …

Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the
proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin …

Background Selective intestinal cobalamin malabsorption with mild proteinuria (Imerslund‐
Gräsbeck syndrome; I‐GS), is an autosomal recessive disorder of dogs caused by mutations …

Background: B vitamins play an important role in homocysteine metabolism, with vitamin
deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We …

Cubilin is a 460-kDa endocytic receptor coexpressed with megalin, a multiligand receptor of
the low-density lipoprotein receptor gene family, at the apical pole of epithelial cells in the …

Incidence of cardiovascular disease (CVD) is remarkably high among patients with chronic
kidney disease (CKD), even in the early microalbuminuric stages with normal glomerular …

Imerslund-Gräsbeck syndrome (IGS) or selective cobalamin malabsorption has been
described in humans and dogs. IGS occurs in Border Collies and is inherited as a …