In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

Abstract The PI3K/AKT/mTOR pathway controls key cellular processes, including
proliferation and tumor progression, and abnormally high activation of this pathway is a …

Background & Aims Hepatoblastoma (HB) is the most frequent childhood liver cancer.
Patients with aggressive tumors have limited therapeutic options; therefore, a better …

Cancer stem cells (CSCs) are the subpopulation of tumor cells with the properties of
tumorigenesis, multilineage differentiation potential and self-renewal, which is the driving …

Although dietary fructose is associated with an elevated risk for pancreatic cancer, the
underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate …

Despite the extensive body of research, understanding the exact molecular mechanisms
governing inflammatory bowel diseases (IBDs) still demands further investigation …

The use of Hypomethylating agents combined with Venetoclax (VH) for the treatment of
Acute Myeloid Leukemia (AML) has greatly improved outcomes in recent years. However …

Ocean acidification (OA) and trace metal pollutants coexist to exert combined effects on the
functions and services of marine ecosystems. Increasing atmospheric carbon dioxide has …

Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal
adenocarcinoma (PDAC) being the most common subtype. Advanced stage diagnosis of …

Cancer cells grown in 3D spheroid cultures are considered more predictive for clinical
efficacy. The marine natural product dragmacidin D induces apoptosis in MDA-MB-231 and …