The present invention relates to chirally controlled oligonucleotides, chirally controlled
oligonucleotide compositions, and the method of making and using the same. The invention …

The present application, among other things, provides technologies, eg, reagents, methods,
etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, eg …

US9695211B2 - Method for the synthesis of phosphorus atom modified nucleic acids - Google
Patents US9695211B2 - Method for the synthesis of phosphorus atom modified nucleic acids …

5,141,813 5,151,510 5,175,273 5,212.295 5,262,530 5,292.875 5,319,080 5,359,044
5,367,066 5.432. 272 5,457,187 5,457,191 5,459,255 5,484,908 5,502,177 5,506,212 …

Solution The present invention relates to an adjuvant which com prises oligonucleotides
which comprise two to four sequences each represented by 5'-X, CpG X2-3'and has a length …

Abstract wherein each nucleic acid at 3′ end and 5′ end of the oligonucleotide is S type
nucleic acid connected by phosphorothioate linkage, and wherein the oligonucleotide …

3,687,808 A 8, 1972 Merigan et al. 3,745,162 A 7/1973 Helsley 4,022,791 A 5/1977 Welch,
Jr. 4,113,869 A 9, 1978 Gardner 4.415, 732 A 11, 1983 Caruthers et al. 4,458,066 A 7, 1984 …

2017-06-14 Assigned to ONTORII, INC. reassignment ONTORII, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ZLATEV, IVAN …

Tulic et al Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy
decreases the nasal inflammatory response J Allergy Olin Immunol pp. 235-241.* IEE et al …

CO7H 1/00(2006. 01) CO7H 23/00(2006. 01) CO7B 53/00(2006. 01) CO7H 19/11(2006. 01)
C07H 19/213(2006. 01) CO7H 21/04(2006. 01) CO7D 405/04(2006. 01) C07D …