Impact of Mediterranean diet on chronic non-communicable diseases and longevity

LJ Dominguez, G Di Bella, N Veronese, M Barbagallo - Nutrients, 2021 - mdpi.com
The average life expectancy of the world population has increased remarkably in the past
150 years and it is still increasing. A long life is a dream of humans since the beginning of …

Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision

B Celli, L Fabbri, G Criner, FJ Martinez… - American journal of …, 2022 - atsjournals.org
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal

BR Celli, LM Fabbri, SD Aaron, A Agusti… - American journal of …, 2021 - atsjournals.org
Over 200 years ago, René Laennec published the first description of emphysema, an
important pathobiological element of what is today known as chronic obstructive pulmonary …

Reversed-engineered human alveolar lung-on-a-chip model

D Huang, T Liu, J Liao, S Maharjan… - Proceedings of the …, 2021 - National Acad Sciences
Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …

Update on the pathogenesis of chronic obstructive pulmonary disease

A Agustí, JC Hogg - New England Journal of Medicine, 2019 - Mass Medical Soc
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

From GOLD 0 to pre-COPD

MLK Han, A Agusti, BR Celli, GJ Criner… - American journal of …, 2021 - atsjournals.org
The diagnosis of chronic obstructive pulmonary disease (COPD) currently requires the
demonstration of poorly reversible airflow limitation, defined as a post-bronchodilator …

Pulmonary rehabilitation for adults with chronic respiratory disease: an official American Thoracic Society clinical practice guideline

CL Rochester, JA Alison, B Carlin… - American journal of …, 2023 - atsjournals.org
Background: Despite the known benefits of pulmonary rehabilitation (PR) for patients with
chronic respiratory disease, this treatment is underused. Evidence-based guidelines should …

[HTML][HTML] Goals of COPD treatment: Focus on symptoms and exacerbations

CF Vogelmeier, M Roman-Rodriguez, D Singh… - Respiratory …, 2020 - Elsevier
Chronic obstructive pulmonary disease (COPD) is currently a leading cause of death
worldwide, and its burden is expected to rise in the coming years. Common COPD …

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial

KF Rabe, BR Celli, ME Wechsler… - The Lancet …, 2021 - thelancet.com
Background Genetic data implicate IL-33 in asthma susceptibility. Itepekimab, a monoclonal
antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic …